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Working Group Recruitment Strategies

The technologies (RNAseq, bioinformatics, etc.) that investigators in both vertebrate and invertebrate systems are exploiting have extensive overlap. Overall, we believe the AG2P network will leverage the technical and biological expertise of both groups, hastening discoveries linking genomes to phenotypes. To accomplish this task, we seek to establish working groups that would be responsible for recommending standard procedures for both experimental and bioinformatic methodologies that fall within their purview. In broad terms, participants for the working groups are requested:

Trait working group: the objective of this group would be to think broadly about the relationships between invertebrates and vertebrates, identifying the evolutionary commonalities and differences that constitute trait determination bridging these disparate animal groups. This group would propose methodologies at the genomic, transcriptomic and bioinformatic level to help reveal the evolutionary origins of unique and shared traits.

Functional annotation group: this group will make recommendations regarding RNAseq, chromatin, histone and DNA methylation mapping, along with genome confirmation HiCstudies.

Bioinformatics working group: This group will work closely with iPlant to develop standard data analysis pipelines along with appropriate database schema and user-friendly Web interfaces. This group will be an important interface between the other working groups and iPlant. This would mean that the AG2P network would have an embedded resource in the iPlant milieu that could meet the needs of any participant.

Phenotype Ontology working group: The objective of this group would be to work with thecurrent Phenotype Ontology RCN to develop terms appropriate to the AG2P efforts and to promote usage of the ontology by members of the AG2P RCN and other members of the scientific community.

Communication, Recruitment and Outreach working group: This group would be responsible for integrating efforts needed for communication within the group (web resources, wikis) and with the larger community (web resources, blogs, social media). These resources, along with RCN sponsored workshops and meetings, will be used as recruitment tools to engage other scientific communities (for example, communities studying insects or fish). This group will also be engaged in developing web based instructional modules suitable for classroom teaching.

Meetings, Workshop and Symposia working group: This group will propose meetings and
workshop themes and identify participants from the AG2P network to lead workshops. The group will also liaise with professional societies to help members of the IVG2P network present at appropriate venues such as Plant and Animal Genome or the Society for Integrative and Comparative Biology meetings (see post on upcoming meeting and workshop). This RCN will have a particular focus on engaging and supporting undergraduate and graduate student involvement in all phases of its work, including participation in working groups, meetings and workshops.

Welcome to the Animal Genome to Phenome Research Coordination Network Website

Welcome to the Animal Genome to Phenome Research Co-ordination Network Website

Understanding the relationship between an organism’s DNA (the genome) and the set of phenotypic characteristics that result from genomic expression (the phenome) is a central challenge in biology. High throughput sequencing and phenotypic data from multiple species provides an opportunity for comparative analysis of genome to phenome data. The objective of the Animal Genome to Phenome Network (AG2PN) Research Collaboration Network (RCN) is to promote comparative analysis of vertebrate and invertebrate animals to enrich our understanding of the relationship between genomes and phenomes. The AG2PN will bring together groups using diverse experimental approaches to understand how the genome ultimately manifests the phenome. The AG2PN will provide tools necessary for scientists to exploit comparative genomics approaches to understand genome to phenome relationships. In addition, the activities of the AG2PN will provide training for undergraduates, graduate students and post-doctoral fellows in the science of comparative biology and genome to phenome relationships. Participation of researchers from universities and colleges serving historically underrepresented groups will be particularly encouraged. The AG2PN will also generate educational modules to further enhance student training in G2P concepts. All of the resources developed by the AG2PN will be freely available to the scientific community, communicated at scientific meetings, and published in peer-reviewed journals.

A major objective of the AG2PN will be to encourage researchers to leave their silos and develop collaborative teams that will exploit comparative approaches to enhance our understanding of genome to phenome relationships. The AG2P RCN goals include: Establishing an international AG2PN with scientists studying a diverse range of animals; AG2PN activities that will directly foster the development of comparative studies by promoting standardization of experimental approaches, data and metadata collection and bioinformatic analyses; promoting new collaborations and proposals among scientists from different specialties through international meetings, web sites, publications and social media; and promoting understanding of comparative genomic studies through the development of training modules using diverse educational modalities. Ultimately, this RCN will improve our understanding of the relationships between selective pressures, genomic changes and phenotypic outcomes. The standards developed by this RCN will find applicability far beyond the science directly affected by the AG2P network. These standards will facilitate laboratory work and data comparability across a broad range of species and studies.